HO-1 유도 Sappanchalcone의 당뇨병성 혈관 염증 억제 효능
Protective Effects of HO-1 Induced Sappanchalcone on Diabetic Vascular Inflammation
이윤정, 리빈, 윤정주, 이소민, 이용표, 김윤철, 강대길, 이호섭,
소속 상세정보
이윤정 ( Lee Yun-Jung ) - 원광대학교 한의과대학 생리학교실
리빈 ( Li Bin ) - 원광대학교 한방체액조절연구센터
윤정주 ( Yoon Jung-Joo ) - 원광대학교 한의과대학 생리학교실
이소민 ( Lee So-Min ) - 원광대학교 한의과대학 생리학교실
이용표 ( Lee Yong-Pyo ) - 원광대학교 한의과대학 생리학교실
김윤철 ( Kim Youn-Chul ) - 원광대학교 약학대학
강대길 ( Kang Dae-Gill ) - 원광대학교 한의과대학 생리학교실
이호섭 ( Lee Ho-Sub ) - 원광대학교 한의과대학 생리학교실
KMID : 0829220130370020067
Abstract
Sappanchalcone, a biologically active compound isolated from Caesalpinia sappan L., is reported to exert a variety of biological activities, such as neuroprotective, anti-inflammatory actions and inhibitory effect on antigen-induced beta hexosaminidase release. However, the vascular protective effects of this compound are not fully understood. The present study examined the effects of sappanchalcone in suppressing cell adhesion molecules expression in high glucose stimulated human umbilical vein endothelial cells (HUVEC). Sappanchalcone significantly decreased 25 mM high glucose-induced vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) expression in a dose-dependent manner. Sappanchalcone also significantly inhibited the formation of intracellular reactive oxygen species (ROS). Furthermore, we found that the vascular protective effects of sappanchalcone were linked to the up-regulation of heme oxygenase-1 expression in HUVEC. The effects of sappanchalcone on the high glucose-induced expression of VCAM-1 and ICAM-1 were partially reversed by treatment of the cells with an inhibitor of HO-1, tin protoporphyrin IX (SnPP). Based on these results, these findings suggest that sappanchalcone-induced HO-1 expression plays a key role in the vascular protective effects of sappanchalcone in HUVEC.
키워드
Sappanchalcone; HUVEC; Heme Oxygenase-1; Cell Adhesion Molecules; ROS
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